Weiler is a Fellow of the American Academy of Arts. He holds degrees from Sussex (BA); Cambridge (LLB and LLM); and The Hague Academy of International Law (Diploma of International Law). He earned his Ph.D. in European Law at the EUI, Florence. He is recipient of several honorary doctorates in law and political science from major universities in Europe and the United States including an honorary doctorate in Theology from The Catholic University of America.

From 1978 to 1985, Weiler was a member of the Department of Law at the European University Institute, Florence, and co-founded its Academy of European Law in 1989. He later served as Professor of Law at the University of Michigan Law School (1985-1992) and as Manley Hudson Professor and Jean Monnet Chair at Harvard Law School (1992-2001).

Weiler served as a member of the Committee of Jurists of the Institutional Affairs Committee of the European Parliament, co-drafting the European Parliament's Declaration of Human Rights and Freedoms and Parliament's input to the Maastricht Inter-intergovernmental Conference. He is a WTO and NAFTA Panelist, and a founding editor of the European Journal of International Law, the European Law Journal, and the World Trade Review.

Weiler is author of articles and books in the fields of international, comparative, and European law. His publications include: Un’Europa Cristiana (Rizzoli, 2003 - translations into German, Polish, Spanish, Portuguese, Slovenian, French, Hungarian, Dutch); European Constitutionalism Beyond the State. Edited with Marlene Wind, (Cambridge Univ. Press, 2003); Integration in an Expanding European Union: Reassessing the Fundamentals. Edited with Ian Begg and John Peterson, (Blackwell Publishing, 2003); Constitution of Europe - do the New Clothes have an Emperor? (Cambridge Univ. Press, 1998 - translations into Spanish, Italian, German, Slovenian, Japanese, Chinese, Greek, Serbian, Portuguese, Romanian in print or in preparation); The EU, the WTO, and the NAFTA: Towards a Common Law of International Trade? (Academy of European Law, EUI, Florence/Oxford Univ. Press, 2000); The European Court of Justice. Edited with Grainne de Burca, (Oxford Univ. Press, 2001) and a novella, Der Fall Steinmann (Piper 2000). See full list of publications.

Weiler's research focus is on issues of European integration, globalization and democracy.

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